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REACTIVO (Anticuerpo o Sonda) APLICACIÓN COMÚN (tipo de tejido)
14-3-3-Sigma Tumores de células granulosas y esteroides
Alfa 1-Actina musculo liso (SMA) Musculo Liso or diferenciacion miofibroblastica
Alfa 1-Antiquimiotripsina Marcador Histiocitico
Alfa-1 antitripsina Deficiencia Alfa-1 antitripsina (tejido hepatico)
ACTH Tumores de la Glandula Pituitaria
Actina, musculo liso (SMA) Musculo liso o diferenciacion miofibroblastica
Actin, muscle-specific (MSA) (HHF-35) Diferenciación de musculo liso y musculo estriado esqueletico 
Adenovirus Infección de Adenovirus 
AFP Hepatoma, Carcinoma Hepatoide, Tumor del Saco de Yolk
ALK (clone 5A4) Linfomas ALK positivos y carcinomas de pulmon
AMACR (P504S) Cancer de Prostata
Amebiasis (Entamoeba Histolytica) Amebiasis reaccion cruzada con histiocitos, ordenar con CD68 tambien. 
Proteina Amiloidea AA Amiloide-Subtipeo de Proteina AA
Proteina Amiloidea P Amiloide-Subtipeo de Proteina P
Receptor de Androgeno Cancer de Mama, Cancer de prostata
Anexina A1 Leucemia de Celulas Peludas, Celulas T, Celulas Myeloides
AP12 (MALT) (FISH) translocacion (11;18) (q21;q21)
Arginasa-1 Carcinoma Hepatocellular, diferenciacion hepatoide
Beta-catenina Fibromatosis, carcinoma metastatico de origen desconocido
BAF47 (INI1) Sarcoma epiteliode o teratoide, MPNST
Bartonella Henselae Enf. rasguno de gato
B72.3 Mesotelioma vs. adenocarcinoma
BCL-1 Igual que Cyclin D1
BCL-2 Linfoma- tipeo, tumor de tejido blando
BCL-6 Linfoma- tipeo preliminar 
Ber-EP4 Mesotelioma vs. adenocarcinoma
BG-8 Mesotelioma vs. adenocarcinoma
BK virus Marcador de infeccion con Polyomavirus BK 
Bob.1 B-cells, celulas plasmaticas
Brachyury Cordoma, Hemangioblastoma
BRAF-V600E anticuerpo (clone VE1) Mutation especific de BRAF-V600E 
BRST-1 (BCA-225) Deteccion de algunos tumores epitelia;es
c-MYC sonda (FISH) Linfoma de Burkitt
C4d Rechazo de organo transplantado
C9 Diagnosis de infarto cardiaco (usado with troponina T)
c-kit (CD117) Estroma de tumores gastrointestinales, celulas mastiles
CA-125 Multiples tumores epiteliales, tambien celulas mesoteliales
CA19-9 Cancer metastasico de origen desconocido
CAIX Clasificacion de carcinoma renal,
Calcitonina Cancer medular de tiroides
Caldesmon Diferenciacion de musculo liso
Calponina Diferenciacion de musculo liso, celulas mioepiteliales
Calretinina Mesotelioma, tumores de corteja adrenal, sex cord stromal tumors
Enferm. por Aranazo del gato Bartonella henselae-infeccion
Catepsina D No usado a menudo
Catepsina K Cancer renal asociado con translocacion TFEB
CD1a Carcinomas timicos, timoma, Celulas de Langerhans 
CD2 (linfocitos T) Leucemia/linfoma, tipeo
CD3 (linfocitos T) Leucemia/linfoma, tipeo
CD4 (Linfocitos Colaboradores T) Leucemia/linfoma, tipeo
CD5 (linfocitos T) Leucemia/linfoma, tipeo (danado por B5)
CD7 (linfocitos T) Leucemia/linfoma, tipeo
CD8 (T-suppressor/cytotoxic) Leucemia/linfoma, tipeo
CD10 (CALLA) Linfoma Tipeo, DFSP vs DF, Tumores de estroma endometrial
CD11c Leucemia tipeo, leucemia de celulas peludas
CD15 Leucemia, mesotelioma vs. adenocarcinoma tipeo
CD20 (L26) Leucemia/linfoma tipeo
CD21 Linfoma de celulas foliculares dendriticas
CD23 Linfoma/leucemia, tipeo
CD25 (IL-2) Linfoma/leucemia, tipeo
CD30 (Ki-1) Linfoma
CD31 Diferenciacion vascular, some histiocitos
CD33 Marcador monocitico
CD34 Clasificacion de tumor de tejido blando/ leucemia ,tipeo
CD38 Diferenciacion de celulas plasmaticas 
CD43 (MT1) Linfoma/leucemia, tipeo
CD44 Burkitt vs non-Burkitt y prognosis de tumor carcinoide
CD45 (LCA) Tumores linfohematopoyeticos
CD45RA (4KB5) Linfoma/leucemia, tipeo
CD45RB Linfoma/leucemia, tipeo
CD45RO (UCHL1) Linfoma, tipeo (Linfocitos T, algunas celulas miloides)
CD45RO (OPD4) Linfoma, tipeo (tincion de celulas CD4+)
CD56 (NCAM) Linfoma, tipeo, diferenciacion neuroendocrina
CD57 (NK-1, Leu 7) linfoma, tipeo,  diferenciacion neuroendocrina
CD61 Megakariocitos, leucemia megakariocitica
CD68 (KP1) Marcador Histiocitico/mieloide/monocitico
CD68 (PG-M1) Marcador, histiocitos, monocitos
CD71 (receptor de transferrina) Celulas eritroides, algunos linfomas
CD74 (LN-2, linfocitos B) Linfoma, tipeo
CD79a (linfocitos B) Linfoma/Leucemia, tipeo
CD82 (KAI-1) Subtipeo de tumores renales
CD99 (MIC-2) Clasificacion de tumores de tejido blando
CD117 (c-kit) Tumores de estroma gastrointestinal, celulas masticas y blasticas
CD123 Tumores de celulas dendriticas plasmacitoides , celulas peludas
CD138 Celulas plasmaticas (varios tumores epiteliales)
CD 163 Marcador histiocitico y monocitico
CDK4 Liposarcoma
CDX2 Cancer metastasico de origen desconocido
CEA (clone COL-1) Mesotelioma vs. adenocarcinoma vs metastasis de origen desconocido
CEA (polyclonal) Hepatoma vs. adenocarcinoma
c-erbB2 (HER2) HER2 overexpresion
Cromogranina A Diferenciacion neuroendocrina
Claudina-1 Perineurioma
Claudina-5 Marcador endotelial
Clusterina Linfoma, tipeo,  marcador de celulas foliculares y dendriticas
CMV (Citomegalovirus) Citomegalovirus, infecction
Coccidioidomycosis Coccidiodomiosis infeccion (reactividad cruzada con Histoplasmosis)
Colageno IV Clasificacion de tumor de tejido blando
COX2 No tiene aplicacion
Cryptococo Criptococco Neoformans, infeccion
Cyclin D1 Linfoma de Celulas de Manto
Cytokeratina 5 Mesotelioma, carcinoma escamoso
Cytokeratina 7 Cancer metastasico de origen desconocido
Cytokeratina 14 Tumores oncociticos
Cytokeratina 15 Diagnosis de tumores cutaneous anexos
Cytokeratina 17 Cancer metastasico de origen desconocido
Cytokeratina 19 Cancer papilar de tiroides, Marcador prognosico en tumores de celulas islotes
Cytokeratina 20 Metastatic carcinoma unknown primary
Cytokeratina AE1/AE3 Tumores epiteliales, hepatoma vs. adenocarcinoma (NOT a Pan-CK)
Cytokeratina HMW (34bE12) Cancer metastasico de origen desconocido, cel. prostaticas basales
Cytokeratina LMW (8,18) Tumores epiteliales de prostata, renales y hepatomas
CXCL13 Linfoma de Linfocitos T inmunoangioblasticos
D2-40 (podoplanina) Mesotelioma, seminoma, tumor limfatico
DBA.44 Leucemia de celula peluda, 
Desmin Diferenciacion de musculo liso y esqueletico
DOG1 Tumor de estroma gastrointestinal (GIST)  (mejor que c-kit, CD117)
Epstein Barr Virus (EBER probe) In-situ hybridization stain for EBV
EBV (LMP-1) Epstein-Barr virus infeccion
E-Cadherina Cancer de Mama lobular vs ductal, precursores eritroides
E. Histolytica Amebiasis- cross reacts with histiocytes, so order CD68 with it
EGFR (pharmDx) Erbitux eligibility (FDA-approved test)
EGFR (31G7) Carcinoma glandulas sudoriparas, tumores escamosos
EGFR amplificacion (FISH) EGFR gene amplification status
EMA Tipeo de linfoma
Emerin util para resaltar la membrana nuclear en Ca. papilar de tiroide
ERCC1 Marcador prognostico en CPCNP (Ca pulmon. cel. no pequenas)
ERG Marcador endotelial de nucleo, subset de carcinoma prostatico
Estrogeno receptor Carcer de Mama marcador prognostico
EWSR1 probe (FISH) Ewing/ PNET, DSRCT, Sarcoma celula clara, condrosarcoma
Factor VIII Marcador megakariocitico
Factor XIIIa Dermatofibroma vs. DFSP
Fascin Celulas Hodgkins, other reticulum cells
Fibroblasto Solamente para investigacion
FLI-1 Sarcoma de Ewings , linfoma linfoblastico
FSH     Tumores de glandula pituitaria
FUS probe (FISH) Low grade fibromyxoid sarcoma, angiomatoid MFH, myxoid liposarc
Galectin-3 Carcinoma papillar de la tiroides
Gastrin Gastrinomas
GATA-3 Cancer de mama, urotelial 
GCDFP-15 Cancer de mama, glandulas sudoriparas y salivales
GFAP Tumores gliales, glandulas salivales
Hormona de crecimiento (GH) Tumores de glandula pituitaria
Giardia Giardia lamblia infection
Glucagon Tumores pancreaticos y endocrinos
GLUT-1 Perineurioma
Glycophorin A Marcador eritroide
Glypican 3 Yolk sac tumor, hepatoma,  adenocarcinoma hepatoide
Granzyme B Tipeo de linfoma
H. Pylori Helicobacter pylori infeccion
HBME-1 Cordoma, carcinoma papilar de tiroide
HbsAg Hepatitis B antigeno de superficie
HCG- beta Cooriocarcinoma
Hemoglobin Erythroid marker
HER-1 Mismo que EGFR
HepPar1 Hepatoma, gastric carcinoma
HER2 immunostain HER2 protein overexpression
HER2 (FISH) HER2 gene amplification status
Herpes Simplex I & II Herpes virus I and II infecction
HHV8 (KSHV) Kaposis sarcoma,  lymphoma
Histoplasmosis Histoplasmosis capsulatum infecction (otras infecciones fungicas)
HIV (p24-gag) Detecta HIV solo en tejidos que contienen celulas foliculares dendriticas
HLA-Dr (LN3) Tipeo de leucemia
HLA-G Trofoblastos intermedios (chorioca, other)
HMB-45 Marcador de melanoma, angiomiolipoma and other PEComas
HPL Tumores de celulas germinales y trofoblasticos
HPV-Pan In-situ hybridization, detecta  VPH types 6, 11, 16, 18, 31, 33, 35, 51
HPV, types 6/11 In-situ hybridization 
HPV, types 16/18 In-situ hybridization 
HPV, types 31/33/51 In-situ hybridization
Inmunoglobulina A Celulas plasmaticas -subclasificacion
Inmunoglobulina G Celuls plasmaticas-subclasificacion
Inmunoglobulina G4 Enfermedades escleroticas relacionadas al IgG4
Inmunoglobulina M Celulas plasmaticas- subclasificacion
IgH-MALT1 (MALT) (FISH) Translocacion(14;18) (q32;q21)
IL-2 (CD25) Lymphoma/leukemia typing
IMP3 (L523S, KOC) Dysplasia marker, marker of serous carcinoma
Inhibin Adrenal cortical tumors, sex-cord stromal tumors
INI-1 (BAF47) Epithelioid sarcoma, teratoid/rhabdoid tumor, MPNST
Insulina Pancreatic endocrine tumors
Kappa-cadenas livianas Plasma cell clonality
Ki-67 (clone K2) Proliferative fraction, viable fat cell membranes, lipoblasts
Ki-67 (clone MIB-1) Proliferative fraction, hyalinizing trabecular tumor of thyroid
Kit Same as c-kit, CD117
Ki-67 (clone SP6) Proliferative fraction
KOC (L523S, IMP3) Dysplasia marker, marker of serous ca
L523S (KOC, IMP3) Dysplasia marker, marker of serous ca
Lambda -cadenas livianas Plasma cell clonality
Laminin Basement membrane marker
LAT T-cells
LCA (CD45) Lymphohematopoetic tumors
LEF-1 Marker of SLL / CLL
LH Pituitary tumors
Lipase Acinar cell tumor of pancreas, other
LN3 (HLA-Dr) Leukemia typing
Lysozyme Myeloid and histiocytic marker
MALT probes (FISH) MALT lymphomas, 3 probes, API2/MALT1 t(11;18) (q21;q21), IgH/MALT1 t(14;18), and BCL6 breakapart probe
Mammaglobina Breast marker, salivary glands, sweat glands
MART-1 (clone A103) Melanoma, adrenal cortical tumors, sex cord-stromal tumors, PEComas
MART-1 (M2-7C10+M29E3) Melanoma, angiomyolipoma and other PEComas
Mast cell tryptasa Mastocytosis
MDM2 Liposarcoma
Mesothelin (clone 5B2) Mesothelioma, serous carcinoma, squamous carcinoma
MIC-2 (CD99) Soft tissue tumor classification
MiTF Melanoma, thyroid tumors, many soft tissue tumors
Mitochondria Oncocytic tumors
MLH1 Hereditary cancer syndromes, mismatch repair gene mutations
MOC-31 Mesothelioma vs. adenocarcinoma
MSA (actina musculo-especifica) HHF-35, smooth muscle and skeletal muscle
MSH2 Hereditary colon cancer syndrome, mismatch repair gene mutations
MSH6 Hereditary colon cancer syndrome, mismatch repair gene mutations
MUC1 Pagets disease
MUC2 Ovarian mucinous carcinoma vs. colorectal carcinoma
MUC4 Marker of low grade fibromyxoid sarcoma
MUC5AC Ovarian mucinous carcinoma vs. colorectal carcinoma
MUC6 Seminal vesicle marker, serous neoplasms of pancreas
MUM1 Lymphoma typing
MYC probes (FISH, 2 probes) Burkitt lymphoma
MYC Protein IHC Assists in diagnosis of tumors with MYC translocatinos
Myeloperoxidasa Myeloid and histiocytic marker
Myosina-cadena pesada Smooth muscle and myeopithelial marker
Myogenina Rhabdomyosarcoma
Myosina,  musculo liso Myoepithelial marker, smooth muscle differentiation
N-Cadherina Metastatic carcinoma unknown primary
Napsin A Lung carcinoma, alveolar macrophages, some renal cell carcinomas
Nestin Neuroendocrine, melanoma, other
NeuN Neuronal marker
Neurofilamento Neural tumors, occasional non-neural tumors
NGFR DFSP, Soft tissue tumor classification
NKI-C3 Melanoma, neural marker, lysosomal marker
NPM AML subset
NKX2.2 Ewing sarcoma / PNET
NKX3.1 Sensitive and specific nuclear marker of prostate carcinoma
NSE Worthless marker, dont use it
NUT Marker of NUT positive midline carcinomas
NY-ESO-1 Synovial sarcoma
2-Oct Lymphoma typing
OCT3/4 Seminoma, embryonal carcinoma
Osteonectina Osteosarcoma, also other sarcomas (not bone-specific)
p16 (INK4) Cervical dysplasia, HPV-associated head and neck squamous carcinomas
P24-gag Detects HIV only in tissues that contain follicular dendritic cells
p27 Research marker
p40 Squamous ca, urothelial ca, myoepithelial
P501S (Prosteina) Prostate marker
P504S (AMACR) Prostate cancer diagnosis
P504S / p63 cocktail Prostate cancer diagnosis
p53 p53 tumor suppressor gene mutations
p57 Molar pregnancy (in conjunction with Ki-67)
p63 Myoepithelial, prostatic basal cell, squamous marker
P63/ P504S cocktail Prostate cancer diagnosis
Pancreatico polypeptido Pancreatic endocrine tumors
Paratiroides- hormona (PTH) Parathyroid tumors
Parvovirus Parvovirus B19 infection
Pax-2 Renal cell carcinoma, serous carcinoma, lymphoid cells
Pax-5 (B-cells) B-cells, some neuroendocrine tumors
Pax-8 Kidney, thyroid, female genital tract carcinomas, some lymphoid cells
PCP (Pneumocystis carinii) Pneumocystis carinii infection
PD-1 Assists in dx of angioimmunoblastic lymphoma
PDEGF Platelet-derived epidermal growth factor
PDGFR-alpha Diagnosis of c-kit negative GISTs (DOG1 is better for this)
PDX1 Stains some pancreatic neuroendocrine tumors
Perforin Lymphoma typing
PE-10 (SP-A) Lung adenocarcinoma and some thyroid carcinomas
PGP9.5 Neural/neuroendocrine marker
PHH3 Mitosis marker
Placental S100 (S100P) Benign vs malignant pancreatic lesions, urothelial ca, other
PLAP Many carcinomas, also some germ cell tumors
PMS2 Hereditary colon cancer syndrome, mismatch repair gene mutations
Pneumocystis (PCP) Pneumocystis carinii infection
Podoplanina (D2-40) Same as D2-40, mesothelioma, lymphatics, seminoma
Polyomavirus (BK, SV-40) Marker of BK Polyomavirus infection
Prealbumin (transthyretin) Choroid plexus tumors, some types of amyloid
Procolageno 1 Fibroblastic differentiation, AFX, also some carcinomas
ProExC Cervical dysplasia
Progesterona- receptor Breast cancer prognostic marker
Prolactina Pituitary tumors
Prosteina (P501S) Prostate marker
PSA (prostate) Prostate marker
PSAP (prostate) Prostate marker (prostatic acid phos), also rectal carcinoid tumors
PSMA (prostate) Prostate marker
PTH Parathyroid tumors
pVHL Renal tumors, clear cell ca fem gen tract, bile duct marker
RB Protein spindle cell / pleomorphic lipoma, myofibroblastoma
RCC (PN-15) Renal cell carcinoma marker (Pax8 is much more sensitive)
Ret oncoprotein Ganglion cells
RON Renal oncocytoma, other
RRM2 Evaluation of urothelial dysplasia
RSV Respiratory Synctitial Virus
Rocky Mountain Spotted Fever Rocky Mountain Spotted Fever bug
S100 Melanoma, neural marker, myoepithelial, other
S100P (Placental S100) Benign vs malignant pancreatic lesions, urothelial ca, other
SALL4 Germ cell tumors, hepatoid adenocarcinoma of stomach
SATB2 Colorectal carcinomas
SDHB SDHB-deficient tumors
Skel. Myosin  MY-32 Skeletal muscle differentiation
SMA (Actina- Musculo liso) Smooth muscle or myofibroblastic differentiation
Miosina- Musculo liso Myoepithelial marker, smooth muscle differentiation
Smoothelin Used to distinguish muscularis mucosa from detrusor in bladder bxs
Somatostatin Pancreatic endocrine tumors
Sox10 Sensitive melanoma marker (better than S100), neural, myoepithelial
SST-2A Somatostatin receptor
Stathmin Cervical dysplasia – CIS
SV-40 (BK, Polyomavirus) Marker of BK Polyomavirus infection
Synaptophysin Neuroendocrine differentiation
Sifilis Treponema pallidum infection
SYT probe, t(X;18) (FISH) Synovial sarcoma
t(11;14) (FISH) Mantle cell lymphoma
t(14;16) (FISH) Follicular lymphoma
TDT Lymphoma/leukemia typing, Merkel cell tumors
Telomerasa Identification of cells with telomerase activity
TFE3 Alveolar soft part sarcoma, some renal tumors
TFEB Some renal tumors
Thrombomodulina Urothelial carcinoma, mesothelioma, squamous tumors
Thymidylate Synthase Prognostic marler
Tyroglobulina Thyroid carcinoma
TIA-1 (cytotoxic) Lymphoma typing
TLE-1 Synovial sarcoma, other tumors
Topoisomerasa Prognostic marker
Toxoplasmosis Toxoplasmosis gondii
Transtiretina (prealbumina) Choroid plexus tumors, some types of amyloid
TRAP Hairy cell leukemia
Troponina T Diagnosis of myocardial infarction (used with C9)
Tripsina Acinar cell tumor of pancreas
Triptasa, mast cell Mast cell marker
TSH Pituitary tumors
TTF-1 Lung & thyroid marker, also some neuroendocrine tumors
Tirosinasa Melanoma maker
Ubiquitin Alzheimer’s disease, recognition of Mallory bodies in liver
Urinario (Panel FISH en urina) Diagnostico Citologico de Cancer de la Vejiga
Varicella Zoster Varicella Zoster infection
VEGF Misc tumors
Villin Metastatic carcinoma unknown primary
Vimentin Metastatic carcinoma unknown primary
VIP Pancreatic endocrine tumors
VS38 Plasma cells, plasmacytoid, epithelial cells
Enfermedad de Whipple Whipple’s disease
WT-1 (6F-H2) Mesothelioma and serous carcinoma marker
ZAP-70 CLL prognostication